Central United States Vacations from $358

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Your Central United States Vacation

When it's time to set off on your next unforgettable adventure, a vacation package to Central United States is the answer. From this destination's friendly locals to all the other incredible things it's renowned for, there's a lot to discover. With so much to see and do on a trip to Central United States, it can be difficult to know where to begin. Kick off your travels in New York at Times Square and Central Park — two leading attractions here. Another great city worthy of a spot on your itinerary is Orlando. Don't miss Universal Studios Florida and Orlando International Premium Outlets. From the moment you book your Central United States vacation to when you return home, Expedia has your back every step of the way.

The Latest Central United States vacation packages

Price found within the past 48 hours. Click for updated prices.
The Allegro Royal Sonesta Hotel Chicago Loop
TimberRose B&B
Hutton Hotel
Hotel Riu Plaza Chicago
Trump International Hotel & Tower Chicago
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Where to stay in Central United States

Find the best Central United States areas and neighborhoods for the activities you enjoy most. Learn more about Central United States

Discover the most popular places to visit in Central United States

Central United States Hotel Deals

Congress Plaza Hotel

Congress Plaza Hotel

3.5 out of 5
520 South Michigan Avenue, Chicago, IL
Fully refundableReserve now, pay when you stay
$168 nightly
The price is $197 total per night from Sep 23 to Sep 24
$197 total
Sep 23 - Sep 24
Total with taxes and fees
7.8/10 Good! (9,216 reviews)
"Could use more front desk staff. Quite a line formed behind me"

Reviewed on Sep 18, 2025

Congress Plaza Hotel
Gaylord Opryland Resort & Convention Center

Gaylord Opryland Resort & Convention Center

4 out of 5
2800 Opryland Drive, Nashville, TN
Fully refundableReserve now, pay when you stay
$407 nightly
The price is $478 total per night from Oct 1 to Oct 2
$478 total
Oct 1 - Oct 2
Total with taxes and fees
8.6/10 Excellent! (1,700 reviews)
"The room was clean and comfortable. Having the options of different places to eat. The water falls and the plants were great."

Reviewed on Sep 15, 2025

Gaylord Opryland Resort & Convention Center
Hilton Garden Inn Chicago Downtown/Magnificent Mile

Hilton Garden Inn Chicago Downtown/Magnificent Mile

3 out of 5
10 E Grand Ave, Chicago, IL
Fully refundableReserve now, pay when you stay
$176 nightly
The price is $207 total per night from Oct 2 to Oct 3
$207 total
Oct 2 - Oct 3
Total with taxes and fees
8.4/10 Very Good! (3,919 reviews)
"Everything was great. Downtown location was awesome. Close to everything. We walked to a restaurant. Would definitely stay here again."

Reviewed on Sep 19, 2025

Hilton Garden Inn Chicago Downtown/Magnificent Mile
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.